Dimethylformamide → HCID 178502856, compound

Participants

Reaction Steps

To a suspension of the amidoxime 3 (1 mmol) in DMF (15 mL) was added LiOH.H2O (6 mmol, in 3 mL H2O) followed by dimethyl sulfate (5 mmol). The reaction was kept stirring overnight after which it was poured onto ice/water and the precipitate was filtered, washed with water and dried to give the desired compound in 92% yield; mp 214-215° C. 1H NMR (DMSO-d6); δ 3.75 (s, 6H), 6.12 (d, J=3.6 Hz, 1H), 6.17 (d, J=3.6 Hz, 1H), 7.76-8.00 (m, 8H).

Provenance & Evidence