6-Chloromethyl-2-methylpyridinium chloride → 3-[2-Methyl-1-(6-methyl-pyridin-2-ylmethyl)-1H-imidazol-4-ylethynyl]-benzonitrile

HRID 2424868Notes

Reaction equation

HRID 2424868 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1.Cl.Cl[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[N:21]=1>>[CH3:1][C:2]1[N:3]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[N:21]=2)[CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1

Participants

3

Reactant 2

HCID 765456-Chloromethyl-2-methylpyridinium chlorideHCID 178432699HCID 178432699, compound

Product 1

HCID 672480443-[2-Methyl-1-(6-methyl-pyridin-2-ylmethyl)-1H-imidazol-4-ylethynyl]-benzonitrile

Procedure

The title compound, MS: m/e=313.2 (M+H+), was prepared in accordance with the general method of example 1 from 3-(2-methyl-1H-imidazol-4-ylethynyl)-benzonitrile and 2-chloromethyl-6-methyl-pyridine hydrochloride.

Sources & evidence

ORD record
ord-452944f943ff463c8f2e8f8ea9ac9b35
Source dataset
uspto-grants-2011_06
Patent number
US07964620B2

Reaction notes

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