2-(Chloromethyl)-3-methylpyridine hydrochloride → 4-[1-(3-Methyl-pyridin-2-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

HRID 2424870Notes

Reaction equation

HRID 2424870 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.Cl.Cl[CH2:18][C:19]1[C:24]([CH3:25])=[CH:23][CH:22]=[CH:21][N:20]=1>>[CH3:25][C:24]1[C:19]([CH2:18][N:13]2[CH:14]=[C:10]([C:9]#[C:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=3)[N:11]=[C:12]2[CH3:15])=[N:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 130586832-(Chloromethyl)-3-methylpyridine hydrochlorideHCID 178418884HCID 178418884, compound

Product 1

HCID 672460554-[1-(3-Methyl-pyridin-2-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

Procedure

The title compound, MS: m/e=303.2 (M+H+), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2-chloromethyl-3-methyl-pyridine hydrochloride.

Sources & evidence

ORD record
ord-8c756739481a4e449ff354c9a13da82e
Source dataset
uspto-grants-2011_06
Patent number
US07964620B2

Reaction notes

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