HRID242491

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CNC(=O)[C@@H](NC(=O)n1nc(-c2cc(F)c(F)cc2F)c2c1CCN(C)C2)C(C)(C)C

HCID46863441

未命名化合物

HCID58124726

未命名化合物

结构：CC(C)(C)OC(=O)N1CCCc2[nH]nc(-c3cc(Cl)ccc3F)c21

HCID59345330

未命名化合物

PRODUCTS

生成物

结构：CN1CCCc2c1c(-c1cc(Cl)ccc1F)nn2C(=O)N[C@H](C(=O)NCCO)C(C)(C)C

HCID46862780

未命名化合物

PROCEDURE

实验过程

Compound 94 was prepared according to the procedure for the synthesis of compound 37 by replacing intermediate 19 with intermediate 20D, and replacing tert-leucine methylamide with intermediate 23. LCMS (+ESI) m/z=466.3 [M+H]+. 1H NMR (CDCl3) δ 7.80 (d, J=8.9 Hz, 1H), 7.62-7.65 (m, 1H), 7.32-7.37 (m, 1H), 7.10 (t, J=9.0 Hz, 1H), 4.14 (d, J=8.9 Hz, 1H), 3.71 (br, 2H), 3.42-3.46 (m, 2H), 3.02-3.06 (m, 2H), 2.96 (br, 2H), 2.41 (s, 3H), 1.92 (br, 2H), 1.06 (s, 9H). Purity: 99%.