HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424922Generated: October 30, 2026
Propyl mercaptan → 6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamide
https://huagongshe.com/reaction/2424922
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propyl mercaptan | HCID 7848 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | 2,6-dichloro-N-cyclohexyl-5-fluoronicotinamide | HCID 59830771 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamide | HCID 59830657 | — |
Reaction Steps
A solution of sodium bis(trimethylsilyl)amide (8.24 mL, 8.24 mmol) in THF (1M) was added to a stirred solution of 1-propanethiol (0.622 mL, 6.87 mmol) in DMF (30 mL) at 5° C., over a period of 3 minutes under air. The resulting suspension was stirred at 20° C. for 15 minutes. 2,6-dichloro-N-cyclohexyl-5-fluoronicotinamide (2.0 g, 6.87 mmol) in DMF (10 mL) was added at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07964618B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-d66198d4be61478197809bb99f111c51 |
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| Source note | uspto-grants-2011_06 |
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