HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (S)-methyl 2-(1-(5-(cyclohexylcarbamoyl)-3-fluoro-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (S)-methyl 2-(piperidin-3-yl)acetate hydrochloride | HCID 45073966 | — |
| Reactant | 6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamide | HCID 59830657 | — |
| Solvent | Butyronitrile | HCID 8008 | — |
| Product | (S)-methyl 2-(1-(5-(cyclohexylcarbamoyl)-3-fluoro-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetate | HCID 58000863 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
(S)-methyl 2-(piperidin-3-yl)acetate hydrochloride (263 mg, 1.36 mmol) was added to 6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamide (500 mg, 1.51 mmol) and potassium carbonate (418 μl, 3.02 mmol) in butyronitrile (20 ml) at room temperature and under air. The resulting suspension was stirred at 120° C. for 80 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964618B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-b0f04bd511e647a0b763b18e8e5d0982 |
| Source note | uspto-grants-2011_06 |