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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424924Generated: October 28, 2026

(S)-methyl 2-(piperidin-3-yl)acetate hydrochloride → (R)-2-(1-(5-(Cyclohexylcarbamoyl)-3-fluoro-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid

https://huagongshe.com/reaction/2424924

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-methyl 2-(piperidin-3-yl)acetate hydrochlorideHCID 45073966—
Reactant6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamideHCID 59830657—
Product(R)-2-(1-(5-(Cyclohexylcarbamoyl)-3-fluoro-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acidHCID 59830628—

Reaction Steps

Prepared in a similar manner to that described above from 6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamide using (S)-methyl 2-(piperidin-3-yl)acetate hydrochloride followed by an ester hydrolysis as described above to give the desired compound (190 mg) as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07964618B2
Source datasetuspto-grants-2011_06
ORD IDord-6c770d5b5c094bc8852310230112399a
Source noteuspto-grants-2011_06