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HRID242496

反应详情

EQUATION

反应方程式

HRID 242496 的结构方程式

REACTANTS

反应物

3
结构：CNC(=O)[C@@H](NC(=O)n1nc(-c2ccc(F)c(F)c2)c2c1CCOC2)C(C)(C)C
HCID46834697

未命名化合物

结构：CC(C)(C)[C@H](N)C(=O)NCCO
HCID58124726

未命名化合物

结构：Fc1ccc(Cl)cc1-c1n[nH]c2c1CCOC2
HCID59345329

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[C@H](NC(=O)n1nc(-c2cc(Cl)ccc2F)c2c1COCC2)C(=O)NCCO
HCID46830664

未命名化合物

PROCEDURE

实验过程

Compound 96 was prepared according to the procedure for the synthesis of compound 28 by replacing intermediate 16 with intermediate 16C, and replacing tert-leucine methylamide with intermediate 23. LCMS (+ESI) m/z=453.3 [M+H]+. 1H NMR (CDCl3) δ 7.82 (d, J=9.3 Hz, 1H), 7.61-7.63 (m, 1H), 7.32-7.36 (m, 1H) 7.09 (t, J=9.2 Hz, 1H), 4.99 (d, J=8.0 Hz, 2H), 4.19 (d, J=9.3 Hz, 1H), 3.78-3.88 (m, 2H), 3.69 (s, 2H), 3.43 (m, 2H), 2.63 (br, 2H), 1.06 (s, 9H). Purity: 91%.