(2S)-2-Amino-3,3-dimethylbutanamide → HCID 46830947, compound

HRID 242499Notes

Reaction equation

HRID 242499 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[CH2:29][O:28][CH2:27][CH2:26][C:11]=3[N:12]([C:14]([NH:16][C@@H:17]([C:22]([CH3:25])([CH3:24])[CH3:23])[C:18]([NH:20]C)=[O:19])=[O:15])[N:13]=2)[CH:5]=[CH:6][C:7]=1[F:8].N[C@H](C(N)=O)C(C)(C)C>>[NH2:20][C:18](=[O:19])[C@@H:17]([NH:16][C:14]([N:12]1[C:11]2[CH2:26][CH2:27][O:28][CH2:29][C:10]=2[C:9]([C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=2)=[N:13]1)=[O:15])[C:22]([CH3:25])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 11297986(2S)-2-Amino-3,3-dimethylbutanamideHCID 46834697(S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methyl-amino)-1-oxobutan-2-yl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide

Product 1

HCID 46830947HCID 46830947, compound

Procedure

Compound 99 was prepared according to the procedure for the synthesis of compound 28 by replacing tert-leucine methylamide with tert-leucine amide.

Sources & evidence

ORD record
ord-7bead7faa8264ece800d79eb1c6271ad
Source dataset
uspto-grants-2014_02
Patent number
US08653127B2

Reaction notes

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