HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-3-(2-Naphthyl)alanine → n-{2-[2(s)-(3-Guanidino-propyl)-5(r)-methyl-4-(2-naphthalen-2-yl-acetyl)-piperazin-1-yl]-1 (r)-naphthalen-2-ylmethyl-2-oxo-ethyl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-3-(2-Naphthyl)alanine | HCID 2733661 | — |
| Reactant | n-{3-[1-(2(r)-Amino-3-naphthalen-2-yl-propionyl)-5(r)-methyl-4-(2-naphthalen-2-yl-acetyl)-piperazin-2(s)-yl]-propyl}-guanidine | HCID 178461576 | — |
| Product | n-{2-[2(s)-(3-Guanidino-propyl)-5(r)-methyl-4-(2-naphthalen-2-yl-acetyl)-piperazin-1-yl]-1 (r)-naphthalen-2-ylmethyl-2-oxo-ethyl}-acetamide | HCID 178475061 | — |
Reaction Steps
The following compound was synthesized by the method of Scheme 6. The compound of Example 38 was treated by the method of Example 36 to introduce an acetyl group at the amino group of the D-2-Nal residue. It was tested as described above with the results shown. The mass was analyzed as 607.7 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964601B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-93b1c17a8be847e194671e017abd670f |
| Source note | uspto-grants-2011_06 |