Acetic Acid → HCID 145723584, compound

HRID 2425010Notes

Reaction equation

HRID 2425010 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:38])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:37])[CH2:16][N:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:26]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[NH:27])[CH:23]=3)[C:18]2=[O:36])=[CH:11][CH:10]=1)C.CC(O)=O>CO>[C:32]([O:31][C:29]([NH:28][C:26](=[NH:27])[C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][CH:21]=1)[C:18](=[O:36])[N:17]([CH2:16][C:15]([C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:7][C:6]([OH:38])=[O:5])=[CH:14][CH:13]=1)=[O:37])[CH2:25]2)=[O:30])([CH3:35])([CH3:33])[CH3:34]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 145723586HCID 145723586, compound

Product 1

HCID 145723584HCID 145723584, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous 0.1N NaOH (11.4 ml; 1.14 mmol) was added to a solution of the compound of example 17a (0.375 g; 0.756 mmol) in MeOH (10 ml), The reaction mixture was stirred at room temperature for 30 min., acidified with AcOH and concentrated. The crude title compound obtained was filtered, washed with cold water and dried under vacuum. Yield, 140 mg.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-e466f916ef3641d489843faef14d8b90
Source dataset
uspto-grants-2011_06
Patent number
US07964628B2

Reaction notes

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