Benzyl Bromide → 1-(3-Nitro-4-phenylmethoxyphenyl)ethanone

Participants

Reaction Steps

1-(4-hydroxy-3-nitro-phenyl)-ethanone was treated with benzyl bromide in the presence of K2CO3 in DMF, and processed as reported in the synthesis of example 20a to obtain the crude product which was purified using flash chromatography (silica gel, 5% CH3CN in chloroform). Yield, 94%; mp, 132° C.; MS (CI): 300 (M++29), 272 (M++1), 91; analysis: C15H13NO4 requires, C, 66.42; H, 4.83; N, 5.16. found; C, 66.58; H, 4.52; N, 5.30%.

Provenance & Evidence