反应详情

Biphenyl-4-sulfonic acid [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(4-hydroxy-butyl)-amide (1 g) was dissolved in tertiarybutylammonium fluoride (15 mL of 1 M in tetrahydrafuran) and stirring for 30 minutes. The solvent was evaporated and the residue dissolved in methylene chloride, washed with water and dried over Na2SO4. The product was purified by column chromatography (ethyl acetate: light petroleum) to give the title compound. δC (DMSO, 62.9 MHz): 25.1, 29.5, 48.9, 51.2, 57.9, 60.3, 127.1, 127.2, 127.6, 128.6, 129.2, 138.1, 138.4 and 144.1.

1. customThe solvent was evaporated
2. dissolutionthe residue dissolved in methylene chloride
3. washwashed with water
4. dry with materialdried over Na2SO4
5. customThe product was purified by column chromatography (ethyl acetate: light petroleum)