4-Fluorobiphenyl → 4'-Fluorobiphenyl sulfonic acid

HRID 2425129ノート

反応式

HRID 2425129 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 94614-FluorobiphenylHCID 24638Chlorosulfonic acid

生成物 1

HCID 181795134'-Fluorobiphenyl sulfonic acid

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

4′-Fluorobiphenyl (5 g) was dissolved in chloroform (100 mL) at room temperature. Chlorosulfonic acid (5 g) was added dropwise and stirring was continued for a further 4 hours, after which the solvent was allowed to slowly evaporate until precipitation was seen. The mixture was left to recrystallised overnight and the solid was collected by filtration. Further crops of crystals were collected from the filtrate.

後処理

  1. customto slowly evaporate until precipitation
  2. waitThe mixture was left
  3. customto recrystallised overnight
  4. filtrationthe solid was collected by filtration
  5. customFurther crops of crystals were collected from the filtrate

出典と根拠

ORDレコード
ord-cac7a01dc1c048cab8ea26a96b5eb42f
出典データセット
uspto-grants-2011_06
特許番号
US07964643B2

反応ノート

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