反应详情

4′-Bromo-2′-fluorobiphenyl (5 g) was dissolved in chloroform (80 mL) at room temperature. Chlorosulfonic acid (5 g) was added dropwise and a precipitate appeared soon after addition was complete. Stirring was continued for a further 4 hours, after which the solid was collected by filtration. Further crops of crystals were collected from the filtrate. The solid was washed with cold chloroform and the washings also allowed to crystallise.

1. additionafter addition
2. filtrationafter which the solid was collected by filtration
3. customFurther crops of crystals were collected from the filtrate
4. washThe solid was washed with cold chloroform
5. customto crystallise