2,4-Difluorophenylboronic acid → [1,1'-Biphenyl]-4-sulfonamide, 2',4'-difluoro-N-(5-hydroxypentyl)-

Participants

Role	Name	HCID	Charge
Reactant	2,4-Difluorophenylboronic acid	HCID 2734334	—
Reactant	4-Bromo-N-(5-hydroxypentyl)benzene-1-sulfonamide	HCID 16094721	—
Product	[1,1'-Biphenyl]-4-sulfonamide, 2',4'-difluoro-N-(5-hydroxypentyl)-	HCID 11631752	—

Reaction Steps

Using a method analogous to that described in Example 40, 4-bromophenyl-sulfonic acid-(5-hydroxypentyl)-amide and 2,4-difluorophenyl boronic acid were reacted to give the title compound as a white solid. δC (CDCl3, 62.9 MHz): 22.7, 29.3, 31.9, 43.1, 62.5, 104.7 (t, J 25.8), 112.0 (dd, J 22.9 and 3.5), 127.3, 129.6, 131.5 (d, J 8.8), 131.5 (d, J 9.8), 139.1, 139.4, 159.8 (dd, J 252.0, 11.7) and 163.0 (dd, J 252.0, 11.7).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07964643B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-7f2d32b0d7c642e1bd439d5e7742440e
Source note	uspto-grants-2011_06