[1,1'-Biphenyl]-4-sulfonamide, N-(4-hydroxybutyl)-2'-nitro- → [1,1'-Biphenyl]-4-sulfonamide, 2'-amino-N-(4-hydroxybutyl)-

Participants

Reaction Steps

2′-Nitrobiphenyl-4-sulfonic acid-(4-hydroxybutyl)-amide (0.5 g) was dissolved in methanol (50 mL). 10% Pd/C (0.5 g) was added and the mixture stirred under hydrogen for 4 hours. The mixture was filtered through celite and evaporated to a brown oil. Column chromatography gave a clear oil, crystallised from ether/petrol to give a white powder. δC (DMSO, 62.9 MHz): 25.9, 29.6, 42.6, 60.3, 115.6, 116.8, 124.1, 126.8, 128.8, 129.3, 129.9, 138.6, 143.8 and 145.2.

Provenance & Evidence