4-Amino-1-butanol → 4-Bromo-3-fluoro-N-(4-hydroxybutyl)benzene-1-sulfonamide

HRID 2425155Notes

Reaction equation

HRID 2425155 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[F:12].[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18]>>[OH:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][S:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[C:3]([F:12])[CH:4]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 258684-Amino-1-butanolHCID 27782184-Bromo-3-fluorobenzenesulfonyl chloride

Product 1

HCID 160947284-Bromo-3-fluoro-N-(4-hydroxybutyl)benzene-1-sulfonamide

Procedure

Using a method analogous to that described in Example 1, 4-bromo-3-fluorophenyl sulphonyl chloride was reacted with 4-aminobutanol, and the title compound obtained as a white solid after recrystallisation from ether/petrol. δC (CDCl3, 62.9 MHz): 26.5, 29.4, 43.2, 62.2, 114.5 (d, J 20.5), 115.3 (d, J 25.4), 123.7 (d, 3.9), 134.5, 141.2 (d, 5.9) and 158.9 (d, J 252).

Sources & evidence

ORD record
ord-590439c917054ee4ad976f1ef239c84d
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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