4-(Trifluoromethyl)phenylboronic acid → HCID 11538374, compound

HRID 2425158Notes

Reaction equation

HRID 2425158 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[C:12]([F:17])[CH:11]=1)(=[O:9])=[O:8].[F:18][C:19]([F:30])([F:29])[C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:23]2[CH:24]=[CH:25][C:20]([C:19]([F:30])([F:29])[F:18])=[CH:21][CH:22]=2)=[C:12]([F:17])[CH:11]=1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 160947284-Bromo-3-fluoro-N-(4-hydroxybutyl)benzene-1-sulfonamide

Product 1

HCID 11538374HCID 11538374, compound

Procedure

Using a method analogous to that described in Example 40, 4-bromo-3-fluorophenyl-sulfonic acid-(4-hydroxybutyl)-amide and 4-trifluoromethylphenyl boronic acid were reacted to give the title compound as a white solid. δC (DMSO, 62.9 MHz): 26.4, 29.5, 43.2, 62.2, 115.4 (d, J 25.4), 123.2, 125.7, 129.4, 130.8 (d, J 22.2), 131.6, 137.6, 141.5 (d, J 6.8) and 159.3 (d, J 253.9).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-289079f068594147bc12742f892a8aa9
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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