2,4-Difluorophenylboronic acid → 3-Chloro-2',4'-difluoro-N-(4-hydroxybutyl)[1,1'-biphenyl]-4-sulfonamide

Participants

Role	Name	HCID	Charge
Reactant	2,4-Difluorophenylboronic acid	HCID 2734334	—
Reactant	4-Bromo-2-chloro-N-(4-hydroxybutyl)benzene-1-sulfonamide	HCID 16094722	—
Product	3-Chloro-2',4'-difluoro-N-(4-hydroxybutyl)[1,1'-biphenyl]-4-sulfonamide	HCID 16094730	—

Reaction Steps

Using a method analogous to that described in Example 40, 4-bromo-2-chlorophenyl-sulfonic acid-(4-hydroxybutyl)-amide and 2,4-difluorophenyl boronic acid were reacted to give the title compound as a white solid. δC (CDCl3, 62.9 MHz): 26.4, 29.5, 41.2, 62.1, 104.9 (t, J 26.0), 112.3 (dd, J 21.3, 2.9), 122.3 (dd, J 12.7, 3.9), 127.5, 131.3, 131.5, 131.5, 131.7 (d, J 2.0), 136.2, 140.6, 159.9 (dd, J 252.0, 11.7) and 163.3 (dd, J 252.0, 11.7).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07964643B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-2a4c975ba622420e9e67014c552244cd
Source note	uspto-grants-2011_06