Phenylpropionylglycine → Rac-3-phenyl-n-{[(phenyl-p-tolyl-methyl)-carbamoyl]-methyl}-propionamide

HRID 2425187Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][C:9]([NH:11][CH2:12][C:13]([OH:15])=O)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]1([CH:22]([NH2:30])[C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:1]1([CH2:7][CH2:8][C:9]([NH:11][CH2:12][C:13](=[O:15])[NH:30][CH:22]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=2)=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 152323Phenylpropionylglycine

HCID 27342954-Methylbenzhydrylamine

Product 1

HCID 59689103Rac-3-phenyl-n-{[(phenyl-p-tolyl-methyl)-carbamoyl]-methyl}-propionamide

Procedure

Prepared in analogy to example 1.1 from (3-phenyl-propionylamino)-acetic acid (CA [56613-60-6]) and rac-C-phenyl-C-p-tolyl-methylamine (CA [55095-21-1]).

Sources & evidence

ORD record: ord-4c5a18c39b7b449180f18d079bd3c132
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07964645B2

Reaction notes

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