4-Isopropylbenzoic Acid → Rac-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-4-isopropyl-benzamide

HRID 2425190Notes

Reaction equation

HRID 2425190 reaction equation
Cl.[NH2:2][CH2:3][C:4]([NH:6][CH:7]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5].[CH:21]([C:24]1[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=1)([CH3:23])[CH3:22]>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([CH:7]([NH:6][C:4]([CH2:3][NH:2][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([CH:21]([CH3:22])[CH3:23])=[CH:25][CH:26]=2)=[O:5])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 108204-Isopropylbenzoic AcidHCID 672464382-Amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride

Product 1

HCID 59689106Rac-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-4-isopropyl-benzamide

Procedure

Prepared in analogy to example 1.12 from rac-2-amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride (Example 3.1) and 4-isopropylbenzoic acid.

Sources & evidence

ORD record
ord-843b35f0d55c4b4fb09f40fb8d27b777
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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