4-Acetylbenzoic Acid → Rac-4-acetyl-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-benzamide

HRID 2425191Notes

Reaction equation

HRID 2425191 reaction equation
Cl.[NH2:2][CH2:3][C:4]([NH:6][CH:7]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5].[C:21]([C:24]1[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=1)(=[O:23])[CH3:22]>>[C:21]([C:24]1[CH:32]=[CH:31][C:27]([C:28]([NH:2][CH2:3][C:4](=[O:5])[NH:6][CH:7]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:29])=[CH:26][CH:25]=1)(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 114704-Acetylbenzoic AcidHCID 672464382-Amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride

Product 1

HCID 59689156Rac-4-acetyl-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-benzamide

Procedure

Prepared in analogy to example 1.12 from rac-2-amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride (Example 3.1) and 4-acetylbenzoic acid.

Sources & evidence

ORD record
ord-76b0115ea884421ca12391e4626dd360
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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