Phenylpropionylglycine → Rac-3-phenyl-n-({[phenyl-(3-trifluoromethyl-phenyl)-methyl]-carbamoyl}-methyl)-propionamide

HRID 2425192Notes

Reaction equation

HRID 2425192 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]([NH:11][CH2:12][C:13]([OH:15])=O)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]1([CH:22]([NH2:33])[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:1]1([CH2:7][CH2:8][C:9]([NH:11][CH2:12][C:13](=[O:15])[NH:33][CH:22]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:30])([F:31])[F:32])[CH:24]=2)=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 152323PhenylpropionylglycineHCID 21528802Phenyl(3-(trifluoromethyl)phenyl)methanamine

Product 1

HCID 59689167Rac-3-phenyl-n-({[phenyl-(3-trifluoromethyl-phenyl)-methyl]-carbamoyl}-methyl)-propionamide

Procedure

Prepared in analogy to example 1.1 from (3-phenyl-propionylamino)-acetic acid (CA [56613-60-6]) and rac-C-phenyl-C-(3-trifluoromethyl-phenyl)-methylamine (CA [70428-92-1]).

Sources & evidence

ORD record
ord-afaa1fea578944f89d079579e7243482
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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