4-(Difluoromethoxy)benzoic acid → HCID 59689171, compound

HRID 2425224Notes

Reaction equation

HRID 2425224 reaction equation
Cl.[NH2:2][CH2:3][C:4]([NH:6][CH:7]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5].[F:21][CH:22]([F:33])[O:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=1>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([CH:7]([NH:6][C:4]([CH2:3][NH:2][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([O:23][CH:22]([F:21])[F:33])=[CH:25][CH:26]=2)=[O:5])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 7373604-(Difluoromethoxy)benzoic acidHCID 672464382-Amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride

Product 1

HCID 59689171HCID 59689171, compound

Procedure

Prepared in analogy to example 1.12 from rac-2-amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride (Example 3.1) and 4-difluoromethoxybenzoic acid.

Sources & evidence

ORD record
ord-72477198640f4a63821c79009abba724
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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