4-Fluorohippuric acid → Rac-4-fluoro-n-({[(4-fluoro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-benzamide

HRID 2425238Notes

Reaction equation

HRID 2425238 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6](=[O:12])[NH:7][CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([NH2:29])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:18][CH:17]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:7][CH2:8][C:9](=[O:11])[NH:29][CH:22]([C:19]2[CH:18]=[CH:17][C:16]([F:15])=[CH:21][CH:20]=2)[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)=[O:12])=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6993414-Fluorohippuric acidHCID 111832724-Fluoro-α-phenylbenzenemethanamine

Product 1

HCID 24900237Rac-4-fluoro-n-({[(4-fluoro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-benzamide

Procedure

Prepared in analogy to example 1.1 from 4-fluoro-hippuric acid (CA [366-79-0]) and rac-C-(4-fluoro-phenyl)-C-phenyl-methylamine (CA [55095-26-6]).

Sources & evidence

ORD record
ord-92071d04b9314edc9eb0c213b2a14a4e
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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