4-Fluorohippuric acid → HCID 24896771, compound

HRID 2425245Notes

Reaction equation

HRID 2425245 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6](=[O:12])[NH:7][CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.Cl.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]([NH2:34])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]([NH:34][C:9]([CH2:8][NH:7][C:6](=[O:12])[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:14][CH:13]=2)=[O:11])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:33])[F:31])[CH:25]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 6993414-Fluorohippuric acidHCID 21528796HCID 21528796, compound

Product 1

HCID 24896771HCID 24896771, compound

Procedure

Prepared in analogy to example 1.1 from 4-fluoro-hippuric acid (CA [366-79-0]) and rac-C-(4-chloro-phenyl)-C-(3-trifluoromethyl-phenyl)-methylamine hydrochloride (CA [49703-70-0]).

Sources & evidence

ORD record
ord-0373c1fd279b4d31a7cb930bcc0ca38e
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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