4-Fluorohippuric acid → HCID 59689160, compound

HRID 2425248Notes

Reaction equation

HRID 2425248 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6](=[O:12])[NH:7][CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]([NH2:34])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)=[CH:19][CH:18]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:7][CH2:8][C:9](=[O:11])[NH:34][CH:23]([C:20]2[CH:19]=[CH:18][C:17]([O:16][CH3:15])=[CH:22][CH:21]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:33])[F:31])[CH:25]=2)=[O:12])=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6993414-Fluorohippuric acidHCID 24688954HCID 24688954, compound

Product 1

HCID 59689160HCID 59689160, compound

Procedure

Prepared in analogy to example 1.1 from 4-fluoro-hippuric acid (CA [366-79-0]) and rac-C-(4-methoxy-phenyl)-C-(3-trifluoromethyl-phenyl)-methylamine (example 4.7).

Sources & evidence

ORD record
ord-1b7d562448834a4c892e26b7122ef814
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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