3-Methyl-2-thenoic acid → 3-Methyl-thiophene-2-carboxylic acid ({[bis-(3-fluoro-phenyl)-methyl]-carbamoyl}-methyl)-amide

HRID 2425256Notes

Reaction equation

HRID 2425256 reaction equation
[NH2:1][CH2:2][C:3]([NH:5][CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1)=[O:4].[CH3:21][C:22]1[CH:26]=[CH:25][S:24][C:23]=1[C:27](O)=[O:28]>>[F:20][C:16]1[CH:15]=[C:14]([CH:6]([NH:5][C:3]([CH2:2][NH:1][C:27]([C:23]2[S:24][CH:25]=[CH:26][C:22]=2[CH3:21])=[O:28])=[O:4])[C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 902693-Methyl-2-thenoic acidHCID 596891532-amino-N-[bis-(3-fluoro-phenyl)-methyl]-acetamide

Product 1

HCID 596891723-Methyl-thiophene-2-carboxylic acid ({[bis-(3-fluoro-phenyl)-methyl]-carbamoyl}-methyl)-amide

Procedure

Prepared in analogy to example 1.12 from 2-amino-N-[bis-(3-fluoro-phenyl)-methyl]-acetamide (example 3.4) and 3-methyl-thiophene-2-carboxylic acid.

Sources & evidence

ORD record
ord-67616b41ae8843569a7bec67945e76c2
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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