Cyclohexanecarboxylic acid → Cyclohexanecarboxylic acid ({[bis-(3-fluoro-phenyl)-methyl]-carbamoyl}-methyl)-amide

HRID 2425257Notes

Reaction equation

HRID 2425257 reaction equation
[NH2:1][CH2:2][C:3]([NH:5][CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1)=[O:4].[CH:21]1([C:27](O)=[O:28])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[F:20][C:16]1[CH:15]=[C:14]([CH:6]([NH:5][C:3]([CH2:2][NH:1][C:27]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[O:28])=[O:4])[C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7413Cyclohexanecarboxylic acidHCID 596891532-amino-N-[bis-(3-fluoro-phenyl)-methyl]-acetamide

Product 1

HCID 59689139Cyclohexanecarboxylic acid ({[bis-(3-fluoro-phenyl)-methyl]-carbamoyl}-methyl)-amide

Procedure

Prepared in analogy to example 1.12 from 2-amino-N-[bis-(3-fluoro-phenyl)-methyl]-acetamide (example 3.4) and cyclohexane-carboxylic acid.

Sources & evidence

ORD record
ord-40c7361fc12e463cab19e1a1d713e6fd
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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