Lithium borohydride → HCID 67247921, compound

Participants

Reaction Steps

To a solution of LiBH4 (450 mg, 20.4 mmol) in THF (20 mL) at 0° C. is added 17 (1.35 g, ˜3.1 mol). The reaction mixture is warmed to room temperature and stirred under inert atmosphere for 2 days. The reaction is quenched with water and extracted with EtOAc. The product is then purified over silica gel eluting with 8% methanol/92% methylene chloride to yield 18 (FIG. 7).

Provenance & Evidence