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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 242533Generated: October 27, 2026

4-(4-Chlorophenyl)-1-[3-(5,11-dihydro-7-hydroxy [1]benzoxepino [2,3-b]pyridin-5-ylidene)propyl]piperidin-4-ol → 5-Chloro-1'-[3-(5,11-dihydro-7-(2-methoxyethyl)oxy[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]spiro[isobenzofuran-1 (3H), 4'-piperidine]

https://huagongshe.com/reaction/242533

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Chlorophenyl)-1-[3-(5,11-dihydro-7-hydroxy [1]benzoxepino [2,3-b]pyridin-5-ylidene)propyl]piperidin-4-olHCID 66757538—
Reactant5-Chloro-1'-[3-(5,11-dihydro-7-hydroxy[1]benzoxepino [2,3-b]pyridin-5-ylidene)propyl]spiro[isobenzofuran-1(3H),4'-piperidine]HCID 66973919—
Product5-Chloro-1'-[3-(5,11-dihydro-7-(2-methoxyethyl)oxy[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]spiro[isobenzofuran-1 (3H), 4'-piperidine]HCID 66973784—

Reaction Steps

The titled compound was prepared by following the procedure of example 175, but replacing the product of example 44 with the product of example 196.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08653096B2
Source datasetuspto-grants-2014_02
ORD IDord-671d4e947cb9413d90123ff7cdee9003
Source noteuspto-grants-2014_02