Lithium borohydride → HCID 67247264, compound

Participants

Reaction Steps

Compound 28 (2.50 g, 4.75 mmol) is added to a solution of LiBH4 (0.525 g, 23.8 mmol) in THF (20 mL) at room temperature under inert atmosphere. The reaction is stirred for 2 days, then quenched with water (5.0 mL) and then extracted with methylene chloride (2 and 25 mL). The combined organic layers are dried over MgSO4 and concentrated in vacuo. The residue is purified using silica gel chromatography with methanol (5%)-methylene chloride (95%) to give compound 29.

Provenance & Evidence