HCID 66758567, compound → 1-[3-(7-(2-Carbamoyl)ethyl-5,1 1-dihydro[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]-4-(4-chlorophenyl)-piperidin-4-ol

HRID 242535Notes

Reaction equation

HRID 242535 reaction equation
C(CO[C:6]1[C:11]2[CH2:12][C:13](=[CH:21][CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][C:27]([C:31]4[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=4)([OH:30])[CH2:26][CH2:25]3)[C:14]3[C:15]([O:20][C:10]=2[CH:9]=[CH:8][CH:7]=1)=[N:16][CH:17]=[CH:18][CH:19]=3)(O)=O.C(CCC1C2C[C:50](=CCCN3CCC(C4C=CC(Cl)=CC=4)(O)CC3)[C:51]3[C:52]([O:57]C=2C=CC=1)=[N:53]C=CC=3)(O)=O>>[C:52]([CH2:51][CH2:50][C:6]1[C:11]2[CH2:12][C:13](=[CH:21][CH2:22][CH2:23][N:24]3[CH2:25][CH2:26][C:27]([C:31]4[CH:32]=[CH:33][C:34]([Cl:37])=[CH:35][CH:36]=4)([OH:30])[CH2:28][CH2:29]3)[C:14]3[C:15]([O:20][C:10]=2[CH:9]=[CH:8][CH:7]=1)=[N:16][CH:17]=[CH:18][CH:19]=3)(=[O:57])[NH2:53]

Participants

3

Reactant 2

HCID 66758567HCID 66758567, compoundHCID 667586081-[3-(7-(2-Carboxy)ethyl-5,11-dihydro[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]-4-(4-chlorophenyl)-piperidin-4-ol

Product 1

HCID 667577941-[3-(7-(2-Carbamoyl)ethyl-5,1 1-dihydro[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]-4-(4-chlorophenyl)-piperidin-4-ol

Procedure

The titled compound was prepared by following the procedure of example 181, but replacing the product of example 133 with the product of example 123.

Sources & evidence

ORD record
ord-f8aa35a4164b4eb1b64905d40ea50d20
Source dataset
uspto-grants-2014_02
Patent number
US08653096B2

Reaction notes

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