HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Boc-amino)piperidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Reactant | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Reactant | (r/s)-3-(Tert-butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)piperidine | HCID 67242812 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (r/s)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)piperidine | HCID 67242500 | — |
Reaction Steps
(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)piperidine (Intermediate 2) can be prepared from 4-bromo-5-isoquinolinesulfonyl chloride and 3-(tert-butoxycarbonylamino)piperidine (AstaTech) according to the method described in Example 1-1, Step A, and then used in the method of Example 1-1, Step B in a similar manner to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964613B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-1e49d1cf4afe4c35af983e34ccdf1e30 |
| Source note | uspto-grants-2011_06 |