3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride → (R/S)-3-(Allylamino)-1-(4-bromo-5-isoquinolinesulfony)pyrrolidine

HRID 2425379Notes

Reaction equation

HRID 2425379 reaction equation
Cl.[NH2:2][CH:3]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[C:12]3[C:13]([Br:21])=[CH:14][N:15]=[CH:16][C:17]=3[CH:18]=[CH:19][CH:20]=2)(=[O:10])=[O:9])[CH2:4]1.Cl.N[C@H:24]1[CH2:28]CN(S(C2C3C(Br)=CN=CC=3C=CC=2)(=O)=O)[CH2:25]1>>[CH2:28]([NH:2][CH:3]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[C:12]3[C:13]([Br:21])=[CH:14][N:15]=[CH:16][C:17]=3[CH:18]=[CH:19][CH:20]=2)(=[O:10])=[O:9])[CH2:4]1)[CH:24]=[CH2:25]

Participants

3

Reactant 2

HCID 672429033-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochlorideHCID 67244372(S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride

Product 1

HCID 67243931(R/S)-3-(Allylamino)-1-(4-bromo-5-isoquinolinesulfony)pyrrolidine

Procedure

3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride can be used in the method of Example 5-1 instead of (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride to obtain the title compound.

Sources & evidence

ORD record
ord-bfdb13a78d3e4a6086b1d87fcfcb5103
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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