(S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride → (R)-3-(Allylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

HRID 2425380Notes

Reaction equation

HRID 2425380 reaction equation
Cl.[NH2:2][C@@H:3]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[C:12]3[C:13]([Br:21])=[CH:14][N:15]=[CH:16][C:17]=3[CH:18]=[CH:19][CH:20]=2)(=[O:10])=[O:9])[CH2:4]1.Cl.N[C@H:24]1[CH2:28]CN(S(C2C3C(Br)=CN=CC=3C=CC=2)(=O)=O)[CH2:25]1>>[CH2:28]([NH:2][C@@H:3]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[C:12]3[C:13]([Br:21])=[CH:14][N:15]=[CH:16][C:17]=3[CH:18]=[CH:19][CH:20]=2)(=[O:10])=[O:9])[CH2:4]1)[CH:24]=[CH2:25]

Participants

3

Reactant 2

HCID 67244372(S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochlorideHCID 67244866(R)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride

Product 1

HCID 67243929(R)-3-(Allylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Procedure

(R)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride can be used in the method of Example 5-1 instead of (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine hydrochloride to obtain the title compound.

Sources & evidence

ORD record
ord-881084d924fa4ce1a1b59005b238edd6
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

Loading…