HRID2425381

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC1CCCN(S(=O)(=O)c2cccc3cncc(Br)c23)C1

HCID67242812

未命名化合物

结构：CC(C)(C)OC(=O)N[C@H]1CCN(S(=O)(=O)c2cccc3cncc(Br)c23)C1

HCID67242852

未命名化合物

PRODUCTS

生成物

结构：COc1ncc(Br)c2c(S(=O)(=O)N3CCC(NC(=O)OC(C)(C)C)C3)cccc12

HCID67243741

未命名化合物

PROCEDURE

实验过程

3-(tert-Butoxycarbonylamino)-1-(2-oxy-4-bromo-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 3) can be obtained by using Intermediate 1 in the method of Example 6-1, Step A instead of Intermediate 1a, and then used in the method of Step B to obtain 3-(tert-butoxycarbonylamino)-1-(4-bromo-1-methoxy-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 4), and then Intermediate 4 can be used in the method of Step C to obtain the title compound.