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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2425389Generated: October 28, 2026

(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → Hydrochloric Acid

https://huagongshe.com/reaction/2425389

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 1514396—
Reactanttert-butyl N-(pyrrolidin-3-yl)carbamateHCID 2757234—
ReactantHCID 67243206HCID 67243206—
ProductHydrochloric AcidHCID 313—
Product(r/s)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidineHCID 67203165—

Reaction Steps

3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 16) can be prepared by using 3-(tert-butoxycarbonylamino)pyrrolidine in the method of Example 19-1, Step A instead of (S)-3-(tert-butoxycarbonylamino)pyrrolidine, and then used in the method of Step B in a similar manner to obtain the title compound as hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07964613B2
Source datasetuspto-grants-2011_06
ORD IDord-35fddea5e8f5419aad15c3b13ff621de
Source noteuspto-grants-2011_06