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3-(Boc-amino)piperidine → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| 反応物 | 4-Fluoroisoquinoline-5-sulfonylchloride | HCID 11856547 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | 1,222.2% |
| 生成物 | (S)-3-(tert-Butoxycarbonylamino)-1-(4-fluoro-5-isoquinolinesulfonyl)piperidine | HCID 67242640 | — |
| 生成物 | (S)-3-Amino-1-(4-fluoro-5-isoquinolinesulfonyl)piperidine | HCID 67244923 | — |
反応手順
(S)-3-(tert-Butoxycarbonylamino)-1-(4-fluoro-5-isoquinolinesulfonyl)piperidine (Intermediate 17a) was prepared from 4-fluoro-5-isoquinolinesulfonyl chloride (172 mg) and 3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method of Example 1-1, Step A, and then used in the method of Example 1-1, Step B in a similar manner to obtain the title compound as hydrochloride (156 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07964613B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-64025c1876444740a21ea476c04a2bd9 |
| 出典メモ | uspto-grants-2011_06 |