HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(pyrrolidin-3-yl)carbamate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| Reactant | 4-Methylisoquinoline-5-sulfonyl chloride | HCID 15487110 | — |
| Reactant | HCID 67242706 | HCID 67242706 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 1-[(4-Methyl-5-isoquinolinyl)sulfonyl]-3-piperidinamine | HCID 67243615 | — |
Reaction Steps
(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-methyl-5-isoquinolinesulfonyl)piperidine can be prepared by using 4-methyl-5-isoquinolinesulfonyl chloride instead of 4-bromo-5-isoquinolinesulfonyl chloride, and 3-(tert-butoxycarbonylamino)pyrrolidine instead of (S)-3-(tert-butoxycarbonylamino)pyrrolidine in the method of Example 1-1, and then the protective group of the resultant can be removed according to the method described in Example 1-1, Step B to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964613B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-e555aef41db14edda2392e9dbdbdb8f6 |
| Source note | uspto-grants-2011_06 |