HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-3-Aminopiperidine, 3-BOC protected → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-3-Aminopiperidine, 3-BOC protected | HCID 1514172 | — |
| Reactant | 4-Methylisoquinoline-5-sulfonyl chloride | HCID 15487110 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 67244497 | HCID 67244497 | — |
| Product | HCID 67244921 | HCID 67244921 | — |
Reaction Steps
(R)-3-(tert-Butoxycarbonylamino)-1-(4-methyl-5-isoquinolinesulfonyl)piperidine was prepared by using 4-methyl-5-isoquinolinesulfonyl chloride instead of 4-bromo-5-isoquinolinesulfonyl chloride, and (R)-3-(tert-butoxycarbonylamino)piperidine instead of (S)-3-(tert-butoxycarbonylamino)pyrrolidine in the method of Example 1-1, and then the protective group of the resultant was removed according to the method described in Example 1-1, Step B to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964613B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-eb3c990f38fc4b1493fae31f1167a068 |
| Source note | uspto-grants-2011_06 |