HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl (piperidin-4-ylmethyl)carbamate → 4-(tert-Butoxycarbonylaminomethyl)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl (piperidin-4-ylmethyl)carbamate | HCID 723429 | — |
| Reactant | (3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514396 | — |
| Reactant | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Reactant | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | 4-(tert-Butoxycarbonylaminomethyl)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67243979 | — |
Reaction Steps
4-Chloro-5-isoquinolinesulfonyl chloride obtained in Reference Example 7 (131 mg) and 4-(tert-butoxycarbonylaminomethyl)piperidine (129 mg, Acros) were used in the method of Example 1-1, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-(tert-butoxycarbonylamino)pyrrolidine, respectively, to obtain the title compound (209 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964613B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-886c94e7f6864df5ab1fc60ab8e691e9 |
| Source note | uspto-grants-2011_06 |