HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R/S)-3-(3-Tetrahydrofuranyl)amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Furfural | HCID 7362 | — |
| Reactant | 3-Oxotetrahydrofuran | HCID 529392 | — |
| Reactant | (S)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 16223985 | — |
| Product | (3R/S)-3-(3-Tetrahydrofuranyl)amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 77253499 | — |
Reaction Steps
Hydrochloride of the compound obtainable in Example 19 and tetrahydrofuran-3-one can be used in the method of Example 4-1 instead of hydrochloride of (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine and furfural, respectively, to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964613B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-a97bdf7d803442088e85628fdb271ed9 |
| Source note | uspto-grants-2011_06 |