Phenyl isocyanate → HCID 67243902, compound

Participants

Reaction Steps

A suspension of Intermediate 40a (75 mg) obtained in Step A in 1,2-dichloroethane (3 ml) was cooled on ice, and added with triethylamine (114 μl) and phenyl isocyanate (21 μl, Tokyo Kasei Kogyo), and the mixture was stirred for 1 hour, and then further stirred at room temperature for 10 hours. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate (5 ml), and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (chloroform:methanol=15:1) to obtain the title compound (33 mg).

Provenance & Evidence