Carbon tetrabromide → HCID 67243714, compound

Participants

Reaction Steps

A solution of (S)-3-[2-(2-hydroxyethoxy)acetyl]amino-1-(tert-butoxycarbonyl)pyrrolidine (4 g) prepared in Step B and carbon tetrabromide (5.52 g, Wako Pure Chemical Industries) in dichloromethane (52 ml) was added with PS (polystyrene)-triphenylphosphine (7.86 g, Aldrich) at 0° C., and the mixture was stirred at the same temperature for 3.5 hours. The insoluble solids were removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate) to obtain the title compound (3.7 g).

Provenance & Evidence