Dimethylamine → HCID 67243468, compound

Participants

Reaction Steps

A solution of (S)-3-[2-(2-bromoethoxy)acetyl]amino-1-(tert-butoxycarbonyl)pyrrolidine (195 mg) prepared in Step C in tetrahydrofuran (2 ml) was added with dimethylamine (2 M solution in tetrahydrofuran, 4.5 ml, Aldrich) at 0° C., and the mixture was stirred at room temperature for 23 hours. The volatile components were evaporated under reduced pressure, and the residue was added with saturated aqueous sodium hydrogencarbonate, and extracted five times with chloroform. The combined organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain the title compound (180 mg).

Provenance & Evidence