Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 66757564 | HCID 66757564 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178515067 | HCID 178515067 | 73.3% |
Reaction Steps
To a solution of the product of Example 364 (1.0 g) in DMF (10 ml) were added sodium azide (0.69 g) and ammonium chloride (0.56 g) and the mixture stirred at 100° C. for 36 hour. Water was added to the reaction mixture, and the precipitate was filtered and washed with ethanol to give the titled compound (800 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08653096B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-8b61b35a8cca47c4be8ff19d7587e503 |
|---|
| Source note | uspto-grants-2014_02 |
|---|
