Formaldehyde → HCID 57864760, compound

Participants

Reaction Conditions

Reaction Steps

(R)-methyl 2-phenyl-2-((trimethylsilyl)methylamino)acetate (1.0 g, 3.98 mmol) was added to a mixture of 37% aqueous formaldehyde (784 mg) and methanol (310 mg) while stirring at 0° C. After two hours K2CO3 (1.0 g) was added and the mixture was stirred for an additional hour. Then, water (10 ml) was added and the mixture was extracted with ethyl acetate (2×50 ml). The combined organic layers were dried with Na2SO4. Concentration under vacuum gave the crude (R)-methyl 2-((methoxymethyl)((trimethylsilyl)methyl)amino)-2-phenylacetate as an oil (theor. max. 3.98 mmol). The product was directly used in the next step without further purification.

Provenance & Evidence