Ethyl chloroformate → HCID 57864748, compound

HRID 2425536Notes

Reaction equation

HRID 2425536 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[O:27][C:26]3[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=3[C@H:14]3[CH2:15][N:16](CC4C=CC=CC=4)[CH2:17][C@@H:13]3[C:12]=2[CH:32]=1>C1(C)C=CC=CC=1>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[O:27][C:26]3[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=3[C@H:14]3[CH2:15][N:16]([C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH2:17][C@@H:13]3[C:12]=2[CH:32]=1

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 57864746HCID 57864746, compound

Product 1

HCID 57864748HCID 57864748, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ethyl chloroformate (5 ml) was added to a solution of trans-5-chloro-2,3,3a,12b-tetrahydro-2-benzyl-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole (470 mg, 1.3 mmol) in toluene (30 ml). The reaction mixture was heated to reflux overnight under inert nitrogen atmosphere to give complete conversion. The resulting dark reaction mixture was concentrated under vacuum to give crude title compound as a black oil. MS: M+1=344 found.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux overnight under inert nitrogen atmosphere
  3. customto give complete conversion
  4. customThe resulting dark reaction mixture
  5. concentrationwas concentrated under vacuum

Sources & evidence

ORD record
ord-177721f7144d4f64949b869d5fc2f0e9
Source dataset
uspto-grants-2011_06
Patent number
US07964739B2

Reaction notes

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